Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats
نویسندگان
چکیده
Epileptic seizures are accompanied by learning and memory impairments. In this study, the effect of low frequency stimulation (LFS) on spatial was assessed in kindled animals followed for one month. Fully rats received LFS at 4 times (immediately, 6 h, 24 h 30 following final kindling stimulation). Applying improved animals’ performance Barnes maze test. This action a decrease NR2B gene expression, an increase expression α subunit calcineurin A increased NR2A/NR2B ratio animals. addition, GABAA receptor γ2 2–3 after applying LFS. The also observed 1 week No significant changes were month administration. Field potential recordings hippocampal CA1 area showed that kindling-induced potentiation field EPSP slope returned to near baseline when measured Therefore, it may be postulated reduced seizure-induced impairments, albeit time-dependently. tandem, prevented alterations described proteins, which potentially important synaptic transmission and/or potentiation. Moreover, depotentiation-like phenomenon possible mechanism underlying action.
منابع مشابه
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ژورنال
عنوان ژورنال: Acta Neurobiologiae Experimentalis
سال: 2021
ISSN: ['0065-1400', '1689-0035']
DOI: https://doi.org/10.21307/ane-2021-006